PET FDG for the detection of recurrent ovarian cancer
Positron emission tomography with 18F-fluoro-2-deoxyglucose for the detection of recurrent ovarian cancer. Takekuma M, Maeda M, Ozawa T, Yasumi K, Torizuka T. Department of Gynecology, Hamamatsu Medical Center, 328 Tomitsukacho, Hamamatsu, 432-8580, Japan, email@example.com. Int J Clin Oncol. 2005 Jun;10(3):177-81
OBJECTIVE: evaluate the usefulness of PET FDG in recurrent ovarian cancer. METHODS: 29 patients with epithelial ovarian cancer were evaluated. Patients in whom there was a suspician of recurrence were studied (CA-125 increased, or abnormal CT or MRI despite normal CA-125). The rates of accurate diagnosis of recurrence achieved using CT/MRI, CA125, and FDG-PET in patients with a definitive diagnosis of relapse were compared. RESULTS: The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG-PET were 84.6% (22/26), 100% (3/3), 100% (22/22), 42.9% (3/7), and 86.2% (25/29), respectively. These values were higher than the corresponding values obtained using CT/MRI or CA125 levels. CONCLUSION: FDG-PET is both more sensitive and accurate than CA-125, CT, or MRI in the detection of ovarian cancer recurrence. PMID: 15990965
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