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July 4th, 2003, 20:34
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Join Date: 2001
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Use of PET in the Preoperative Staging of NSCLC (NEJM)
TITLE: Preoperative Staging of Non–Small-Cell Lung Cancer with Positron-Emission Tomography
REF: NEJM Volume 343:254-261 July 27, 2000 http://content.nejm.org/cgi/content/abstract/343/4/254
STUDY TYPE: prospective comparison of the workup of NSCLC patients both with and without the use of FDG PET
PATIENTS: 102 patients with suspected resectable NSCLC
FINDINGS: unexpected distant metastatic disease was found in 11/102 patients (11%). PET altered the cancer stage in 62 patients - the stage was lowered in 20 patients and raised in 42. PET was better than CT in terms of sensitivity (91% vs 75%) and specificity (86% vs 66%) for mediastinal lymph nodes.
CONCLUSION: PET improves the rate of detection of local and distant metastases in patients with non–small-cell lung cancer.
COMMENT: Similar studies also show that the rate of finding unexpected metastatic disease is between 10% and 20%. Currently, it appears that the use of CT alone is inadequate in the preoperative evaluation of NSCLC patients.
Last edited by sysadmin : July 5th, 2003 at 08:09.
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