[J Nucl Med] Integration of Automatically Measured Transient Ischemic Dilation Ratio into Interpretation of Adenosine Stress Myocardial Perfusion SPECT for Detection of Severe and Extensive CAD.

Abidov A, Bax JJ, Hayes SW, Cohen I, Nishina H, Yoda S, Kang X, Aboul-Enein F, Gerlach J, Friedman JD, Hachamovitch R, Germano G, Berman DS.

"The automatically measured TID ratio is a useful clinical marker that is sensitive and highly specific for identification of severe and extensive CAD in patients undergoing adenosine MPS. Integration of abnormal TID ratio into the dual-isotope MPS image interpretation algorithm improves the identification of severe and extensive CAD in adenosine MPS. "

http://jnm.snmjournals.org/cgi/content/full/45/12/1999

http://www.ncbi.nlm.nih.gov/entrez/...t_uids=15585473

J Nucl Med. 2004 Dec;45(12):1999-2007.

COMMENT:

An excellent article. A strong argument for the TID ratio. It sounds like their next step will be looking at region TID ratios.

The authors had a cutoff for normal TID of >1.36 using the dual isotope method. A cutoff for single isotope methods, and for exercise stress is not described in the article.

The TID ratio was based on the summed gated data. They did not look at the EDV or the ESV ratios in this article. My data suggests that the ESV ratio may be more accurate than the TID ratio.