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July 5th, 2003, 08:04
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Join Date: 2001
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PET Detects Unexpected Metastatic Disease in 11% of NSC Lung Cancer Patients
TITLE: Staging Non-Small Cell Lung Cancer by Whole-Body Positron Emission Tomographic Imaging
REF: Ann Thorac Surg 1995;60:1573-1581 http://ats.ctsnetjournals.org/cgi/c.../full/60/6/1573
STUDY TYPE: prospective trial
PATIENTS: 99 patients referred to PET. 67 were for staging of known NSCLC and 32 for diagnosis of a pulmonary nodule that ultimately proved to be NSCLC
FINDINGS: unexpected distant metastatic disease was found in 11 patients with no false-positive results. Sensitivity for detecting N2 disease was 83% and specificity 94%. This was much better than the performance of CT, which had a sensitivity of 63% and a specificity of 73%. FDG PET was normal in 19 patients that had an abnormal CT suggestive of distant metastases. Of these, FDG PET was falsely negative in 1/19.
CONCLUSION: FDG PET is superior to CT in the detection of mediastinal and distant metastases in NSCLC. |
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