OBJECTIVE: to compare the performance of tetrofosmin compared to sestamibi in myocardial perfusion SPECT imaging. METHODS: 19 patients with known coronary artery disease were studied. All patients initially underwent perfusion rest-stress SPECT imaging with sestamibi. Dobutamine stress was used in all patients. A week later, all patients underwent tetrofosmin SPECT imaging. Results were compared with findings on angiography. The time from injection to imaging was 60 minutes for the sestamibi study, and 30 minutes for the tetrofosmin study. RESULTS: When comparing sestamibi versus tetrofosmin, there was no significant differences in the heart-to-liver or heart-to-lung ratios. A head-to-head segmental analysis showed good correlation between sestamibi and tetrofosmin tracers. The overall accuracy of each tracer, compared with angiographic findings, was statistically identical, at 84% for sestamibi and 82% for tetrofosmin. Furthermore, tetrofosmin showed a better reversibility degree (55%) in a shorter time when compared to sestamibi (25%) in perfusion defects, especially in segments with severely decreased perfusion or no uptake. CONCLUSION: tetrofosmin and sestamibi have a similar diagnostic performance. Tetrofosmin has the advantage in that imaging can begin at 30 minutes after injection, compared to 60 minutes after injection for sestamibi. PMID: 15909491

Ann Nucl Med. 2005 Apr;19(2):115-22. Related Articles, Links


Dobutamine stress tetrofosmin SPECT; evaluation of short rest-stress protocol and head to head comparison with MIBI in detection of coronary artery disease.

Turgut B, Unlu M, Cengel A.

Department of Nuclear Medicine, Cumhuriyet University School of Medicine, Sivas, Turkey. bturgut@cumhuriyet.edu.tr


http://www.ncbi.nlm.nih.gov/entrez/...9491&query_hl=1

ncupdate 2005