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Old July 15th, 2005, 21:47
sysadmin sysadmin is offline
Join Date: 2001
Posts: 1,085
Outcome of ablation of thyroid remnants with 100 mCi (3.7 GBq) iodine-131 in patients

these researchers evaluated the efficacy of 100 mCi (3.7 GBq) iodine-131 after total thyroidectomy in 186 patients with differentiated thyroid cancer without metastases. At 6 to 12 months after ablation, 155/186 patients (83%) had a negative scan. Diagnostic scanning with 5 mCi (185 MBq) performed 72 h or 3 months before ablation did not cause stunning in terms of treatment success. There were no significant differences in terms of age, sex, histological type or size of the primary tumor. 11% of the patients with low stimulated Tg (< 2 ng/ml) presented discrete thyroid bed uptake on follow-up diagnostic scan (< 0.5%) without definitive residual disease and 89% had negative uptake on scan. An ablative dose of 100 mCi shows a high rate of efficacy, especially when cervical uptake is < 2%. follow-up diagnostic scan can be avoided in low risk patients with stimulated Tg < 2 ng/ml.
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